Károly MAZÁK
Education
PhD in Chemistry, Budapest University of Technology and Economics, Hungary, 2004
MSc in Biology, Chemistry and English, Eötvös Loránd University, Budapest, Hungary, 1997
Employment
Adjunct Faculty member of the Pre-Medical Track at McDaniel College Budapest - since 2006
After Károly received his MSc degree in 1997, he joined the Department of Pharmaceutical Chemistry, Semmelweis University, where he currently works as an Associate Professor. In 1999, he translated Attila Villányi’s Chemistry problem solving book titled How to get an A in Chemistry into English. He received his Ph. D. degree in 2005. In 2012 and 2013, he spent a year as Research Associate with Prof. C. K. Larive at the Chemistry Department of University of California, Riverside, USA. His research interests include microspeciation of biomolecules, physicochemical profiling of drug molecules and the chemistry of membrane penetration and receptor-binding. At Semmelweis University, he teaches Pharmaceutical Chemistry to Hungarian, English and German students.
Some important publications:
Boglárka Tűz, Béla Noszál, Sándor Hosztafi, Károly Mazák: β-cyclodextrin complex formation and protonation equilibria of morphine and other opioid compounds of therapeutic interest. Eur. J. Pharm. Sci., 171, 106120, 2022
István Köteles, Károly Mazák, Gergő Tóth, Boglárka Tűz, Sándor Hosztafi: Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. Molecules, 25(17), 4009, 2020
Károly Mazák, Béla Noszál: Physicochemical properties of zwitterionic drugs in therapy. ChemMedChem 15, 1102–1110, 2020
Károly Mazák, Béla Noszál and Sándor Hosztafi: Advances in the physicochemical profiling of opioid compounds of therapeutic interest ChemistryOpen 8, 879-887, 2019
Károly Mazák, Béla Noszál: Advances in microspeciation of drugs and biomolecules: species-specific concentrations, acid-base properties and related parameters. J. Pharm. Biomed. Anal. 130, 390-403, 2016
Károly Mazák, Béla Noszál: Drug delivery: a process governed by species-specific lipophilicities. Eur. J. Pharm. Sci., 62, 96-104, 2014
Károly Mazák: Pharmazeutische Chemie. Qualitätskontrolle von Medizinischen Verbindungen und Pharmazeutischen Präparaten. Budapest, 2013.
Károly Mazák, Gergő Tóth, József Kökösi, and Béla Noszál: Thyroxine lipophilicity is dominated by its zwitterionic microspecies. Eur. J. Pharm. Sci., 47, 921-925, 2012
Károly Mazák, Béla Noszál: Zwitterions can be predominant in membrane penetration of drugs: an experimental proof. J. Med. Chem., 55, 6942−6947, 2012
Károly Mazák (Ed.) Pharmaceutical chemistry. The quality control of medicinal compounds and pharmaceutical preparations. Budapest, Semmelweis Publisher, 2010. ISBN: 978 963 9879 86 7
Courses taught
CHE 1122 Essentials of Chemistry